![]() d, The time course of statin use and lowering of LDL-C levels in CRS and GRS participants potentially mirrors significant changes in information seeking and sharing LDL-C decreased from baseline significantly more in GRS participants, due to higher statin use relative to CRS participants. c, Sharing radius (see Figure S3) at 3 months post-disclosure, with distribution skewed towards a maximum score Σ=4 for GRS participants. b, Information sharing at 3 months post-disclosure, with significant p-values (*P<0.05) for the mean difference between values at 3 and 6 months post-disclosure. a, Internet use and EHR/PHR access at baseline and/or 3 and 6 months after risk disclosure, with significant p-values (*P<0.05) for the mean difference between values at 3 and 6 months post-disclosure shared decision-making for statin initiation and documentation of subsequently lowered LDL-c levels in the chart are completed by or at 3 months post-disclosure, prior to observation of significant changes in information seeking and sharing survey responses between the CRS and GRS groups from 3 to 6 months post-disclosure. Six-month post-disclosure, genetic risk score participants were more likely than conventional risk score participants to visit a website to learn about CHD (odds ratio, 4.88 P=0.01), use the internet for information about how genetic factors affect CHD risk (OR, 2.11 P=0.04), access their CHD risk via a patient portal (OR, 2.99 P=0.01), and discuss their CHD risk with others (OR, 3.13 P=0.01), particularly their siblings (OR, 1.92 P=0.03), extended family (OR, 3.8 P=0.01), coworkers (OR, 2.42 P=0.03), and primary care provider (PCP OR, 2.00 P=0.03).ĭisclosure of a genetic risk score for CHD increased information seeking and sharing.Ĭoronary disease electronic health records genetic testing polymorphism, genetic. Information sharing was assessed post-disclosure. Surveys assessing information seeking were completed before and after risk disclosure. CHD risk was disclosed by a genetic counselor and then discussed with a physician. The MI-GENES study (Myocardial Infarction Genes) randomized participants (n=203) aged 45 to 65 years who were at intermediate CHD risk based on conventional risk factors and not on statins to receive their conventional risk score alone or also a genetic risk score based on 28 variants. We hypothesized that disclosing genetic risk for CHD to individuals influences information seeking and sharing. ![]() Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known. ![]()
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